NFL Week 3: Buffalo Bills vs. Miami Dolphins

The Week 3 Thursday Night Football clash kicks off with the Buffalo Bills hosting the Miami Dolphins. Buffalo enters as heavy favorites, but divisional games rarely come easy — especially against Miami’s speed-driven offense. Here’s a full breakdown of the matchup, betting lines, and our prediction.

Game Details:

• Matchup: Miami Dolphins @ Buffalo Bills
• Date/Time: Thursday, Sept. 19 – 8:15 PM ET
• Location: Highmark Stadium, Orchard Park, NY
• Broadcast: Prime Video
• Line: Bills –12.5
• O/U: 51.5

Keys to the Game

Buffalo Bills

• QB Josh Allen looks sharp early in the season, and his connection with Stefon Diggs remains elite.
• The Bills’ defense is one of the most physical in football, ranked near the top against the run.
• The challenge: containing Miami’s speed without giving up explosive plays.

Miami Dolphins

• Miami’s offense can score quickly — Tua Tagovailoa, Tyreek Hill, and Jaylen Waddle are matchup nightmares.
• The Dolphins’ offensive line is still inconsistent, which could leave Tua under pressure all night.
• Defensively, Miami struggles against strong rushing teams — something Buffalo will look to exploit with James Cook.

Prediction

Buffalo is simply the deeper, more complete team at this stage. Miami has the weapons to make a couple of splash plays, but sustaining drives against the Bills’ front seven will be difficult. Expect Allen to make enough big plays with both his arm and legs to keep Buffalo in control.