 
                  1. Adjusting Without Puka Nacua
The Rams’ star receiver, Puka Nacua, who leads the league in receptions and is second in receiving yards, has been ruled out for this game due to an ankle injury. 
With Nacua unavailable, the Rams will need others to step up — notably Davante Adams and the receiving committee behind him. For the Rams, finding production in the passing game is critical given this injury. 
2. Jaguars’ Takeaway-Driven Defense
The Jaguars’ defense is among the NFL leaders in forced takeaways — a key strength. For them to win, continuing that trend is vital. 
If they can force turnovers and control time of possession, they’ll increase their chances of pulling the upset in London.
3. Travel & International Context
Playing in London introduces additional travel and logistical complexities. The Rams must overcome that extra factor (jet-lag, time zone, etc.) while the Jaguars are more battle-tested in international games. 
Also, both squads are at 4-2, so this game has playoff-implication flavor for each.
4. Offensive Line / Running Game Concerns for Jaguars
One of the concerns for Jacksonville is its recent struggles in the run game, compounded by some shaky offensive line play. If they can’t establish a balanced attack, they may struggle to control the clock or keep the Rams’ defense off the field.
📊 Team Comparisons
| Category | Rams | Jaguars | 
|---|---|---|
| Record | 4-2 | 4-2 | 
| Pass Defense Rank (approx) | Defense is strong in takeaways but run defense/OL issues noted | Weaknesses in certain areas; susceptible to big plays (per preview) | 
| Points Allowed | More used to London games, maybe a slight edge | Defense is strong in takeaways, but run defense/OL issues noted | 
| Offensive Question Marks | Missing Nacua; can the offense adapt? | Can the run game / OL rebound? Can Lawrence lead the way? | 
| Venue / Travel | Long travel, international setting | More used to London games, maybe slight edge |